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Aliases for STRIP2 Gene

Aliases for STRIP2 Gene

  • Striatin Interacting Protein 2 2 3 5
  • Family With Sequence Similarity 40, Member B 2 3
  • Protein FAM40B 3 4
  • FAM40B 3 4
  • FAR11 Factor Arrest 11 Homolog B (Yeast) 2
  • FAR11 Factor Arrest 11 Homolog B 3
  • Homolog Of Yeast FAR11 Protein 2 3
  • Striatin-Interacting Protein 2 3
  • KIAA1170 4
  • FAR11B 3

External Ids for STRIP2 Gene

Previous HGNC Symbols for STRIP2 Gene

  • FAM40B

Previous GeneCards Identifiers for STRIP2 Gene

  • GC07P129074

Summaries for STRIP2 Gene

GeneCards Summary for STRIP2 Gene

STRIP2 (Striatin Interacting Protein 2) is a Protein Coding gene. An important paralog of this gene is STRIP1.

UniProtKB/Swiss-Prot for STRIP2 Gene

  • Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Additional gene information for STRIP2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for STRIP2 Gene

Genomics for STRIP2 Gene

GeneHancer (GH) Regulatory Elements for STRIP2 Gene

Promoters and enhancers for STRIP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J129433 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.1 111 1.7 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF143 FOS KLF13 SP3 STRIP2 ENSG00000243679 ENSG00000243302 ENSG00000230715 ENSG00000242588 NRF1 RPS10P15 ENSG00000229413 CDC26P1 RNU7-16P
GH07J129367 Enhancer 1.1 Ensembl ENCODE 10.4 -66.2 -66226 2 CLOCK ATF1 ARID2 ZNF207 ZNF143 ATF7 RUNX3 DEK JUNB REST STRIP2 GC07M129358 LOC105375500 AHCYL2
GH07J129375 Enhancer 0.7 ENCODE 11.7 -58.9 -58905 1 ZNF687 NR2F1 PAX8 MEF2B DPF2 ZNF592 ZNF217 TARDBP IKZF1 POU5F1 AHCYL2 RNU7-16P STRIP2 ENSG00000243230 GC07M129358 LOC105375500
GH07J129472 Enhancer 0.7 ENCODE 11 +38.1 38112 0.2 CTCF CEBPG IRF4 RAD21 RFX5 CC2D1A E2F8 ARID2 ZSCAN5C SMC3 ENSG00000243230 AHCYL2 RNU7-16P STRIP2 ENSG00000244036 SNRPGP3 GC07P129449
GH07J129776 Enhancer 1.5 FANTOM5 Ensembl ENCODE 4.5 +345.1 345053 6.4 HDGF CLOCK ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 FOS SP3 TNPO3 KLHDC10 UBE2H ENSG00000273329 SMKR1 FLNC STRIP2 GC07M129785 MIR183
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around STRIP2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for STRIP2 Gene

Genomic Locations for STRIP2 Gene
53,967 bases
Plus strand
53,967 bases
Plus strand

Genomic View for STRIP2 Gene

Genes around STRIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
STRIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for STRIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for STRIP2 Gene

Proteins for STRIP2 Gene

  • Protein details for STRIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Striatin-interacting protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8WUZ4

    Protein attributes for STRIP2 Gene

    834 amino acids
    Molecular mass:
    95360 Da
    Quaternary structure:
    • Component of striatin-interacting phosphatase and kinase (STRIPAK) complex (By similarity). Interacts with CTTNBP2NL.
    • Sequence=BAA86484.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for STRIP2 Gene


neXtProt entry for STRIP2 Gene

Post-translational modifications for STRIP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for STRIP2 Gene

Domains & Families for STRIP2 Gene

Gene Families for STRIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for STRIP2 Gene


Suggested Antigen Peptide Sequences for STRIP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the STRIP family.
  • Belongs to the STRIP family.
genes like me logo Genes that share domains with STRIP2: view

Function for STRIP2 Gene

Molecular function for STRIP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.

Gene Ontology (GO) - Molecular Function for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with STRIP2: view
genes like me logo Genes that share phenotypes with STRIP2: view

Animal Model Products

miRNA for STRIP2 Gene

miRTarBase miRNAs that target STRIP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for STRIP2 Gene

Localization for STRIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for STRIP2 Gene

Cytoplasm. Note=Enriched in lamellipodia.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for STRIP2 gene
Compartment Confidence
cytosol 5
nucleus 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA,IEA 21834987
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with STRIP2: view

Pathways & Interactions for STRIP2 Gene

SuperPathways for STRIP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for STRIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007010 cytoskeleton organization IMP 21834987
GO:0008360 regulation of cell shape IMP 21834987
GO:0016477 cell migration IMP 21834987
genes like me logo Genes that share ontologies with STRIP2: view

No data available for Pathways by source and SIGNOR curated interactions for STRIP2 Gene

Drugs & Compounds for STRIP2 Gene

No Compound Related Data Available

Transcripts for STRIP2 Gene

mRNA/cDNA for STRIP2 Gene

Unigene Clusters for STRIP2 Gene

Striatin interacting protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for STRIP2 Gene

No ASD Table

Relevant External Links for STRIP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for STRIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for STRIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for STRIP2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x8.2), Brain - Caudate (basal ganglia) (x7.9), Brain - Putamen (basal ganglia) (x7.4), and Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for STRIP2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (29.1) and Heart (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for STRIP2 Gene

Protein tissue co-expression partners for STRIP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of STRIP2 Gene:


SOURCE GeneReport for Unigene cluster for STRIP2 Gene:


Evidence on tissue expression from TISSUES for STRIP2 Gene

  • Nervous system(4.4)
  • Kidney(4.1)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with STRIP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for STRIP2 Gene

Orthologs for STRIP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for STRIP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia STRIP2 34 33
  • 99.72 (n)
(Canis familiaris)
Mammalia STRIP2 34 33
  • 93.05 (n)
(Bos Taurus)
Mammalia STRIP2 34 33
  • 92.57 (n)
(Mus musculus)
Mammalia Strip2 16 34 33
  • 90.25 (n)
(Monodelphis domestica)
Mammalia STRIP2 34
  • 87 (a)
(Rattus norvegicus)
Mammalia LOC500066 33
  • 84.72 (n)
(Ornithorhynchus anatinus)
Mammalia STRIP2 34
  • 84 (a)
(Gallus gallus)
Aves STRIP2 34
  • 79 (a)
FAM40B 33
  • 76.57 (n)
(Anolis carolinensis)
Reptilia STRIP2 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia strip2 33
  • 69.2 (n)
Str.15326 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8705 33
(Danio rerio)
Actinopterygii strip2 34
  • 72 (a)
LOC556392 33
  • 70.39 (n)
Dr.14188 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10622 33
fruit fly
(Drosophila melanogaster)
Insecta CG11526 34
  • 43 (a)
(Caenorhabditis elegans)
Secernentea farl-11 34 33
  • 50.28 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAR11 34
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
Cin.1783 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1783 33
Species where no ortholog for STRIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for STRIP2 Gene

Gene Tree for STRIP2 (if available)
Gene Tree for STRIP2 (if available)
Evolutionary constrained regions (ECRs) for STRIP2: view image

Paralogs for STRIP2 Gene

Paralogs for STRIP2 Gene

(3) SIMAP similar genes for STRIP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with STRIP2: view

Variants for STRIP2 Gene

Sequence variations from dbSNP and Humsavar for STRIP2 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000001238 -- 129,440,456(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000014712 -- 129,439,361(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000119000 -- 129,454,689(+) G/A intron_variant
rs1000195978 -- 129,451,062(+) A/G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000222626 -- 129,446,619(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for STRIP2 Gene

Variant ID Type Subtype PubMed ID
esv2674446 CNV deletion 23128226
esv3614998 CNV loss 21293372
nsv831128 CNV gain 17160897
nsv966886 CNV duplication 23825009

Variation tolerance for STRIP2 Gene

Residual Variation Intolerance Score: 7.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.30; 70.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for STRIP2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for STRIP2 Gene

Disorders for STRIP2 Gene

Additional Disease Information for STRIP2

No disorders were found for STRIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for STRIP2 Gene

Publications for STRIP2 Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 2 3 4 58
  2. TORC2 signaling is antagonized by protein phosphatase 2A and the Far complex in Saccharomyces cerevisiae. (PMID: 22298706) Pracheil T … Liu Z (Genetics 2012) 2 3 58
  3. The protein factor-arrest 11 (Far11) is essential for the toxicity of human caspase-10 in yeast and participates in the regulation of autophagy and the DNA damage signaling. (PMID: 22782902) Lisa-Santamaría P … Revuelta JL (The Journal of biological chemistry 2012) 2 3 58
  4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. (PMID: 21834987) Bai SW … Ridley AJ (BMC biology 2011) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for STRIP2 Gene

Sources for STRIP2 Gene

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