Aliases for IFNB1 Gene
External Ids for IFNB1 Gene
Previous HGNC Symbols for IFNB1 Gene
Previous GeneCards Identifiers for IFNB1 Gene
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
GeneCards Summary for IFNB1 Gene
IFNB1 (Interferon Beta 1) is a Protein Coding gene. Diseases associated with IFNB1 include Primary Progressive Multiple Sclerosis and Newcastle Disease. Among its related pathways are Toll-like Receptor Signaling Pathway and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include cytokine activity and type I interferon receptor binding. An important paralog of this gene is IFNE.
UniProtKB/Swiss-Prot for IFNB1 Gene
Has antiviral, antibacterial and anticancer activities.