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Aliases for FUS Gene

Aliases for FUS Gene

  • FUS RNA Binding Protein 2 3 5
  • Heterogeneous Nuclear Ribonucleoprotein P2 2 3
  • Translocated In Liposarcoma Protein 3 4
  • 75 KDa DNA-Pairing Protein 3 4
  • Fused In Sarcoma 2 3
  • Oncogene FUS 3 4
  • Oncogene TLS 3 4
  • TLS 3 4
  • Fusion (Involved In T(12;16) In Malignant Liposarcoma) 2
  • Fusion, Derived From T(12;16) Malignant Liposarcoma 2
  • Fusion Gene In Myxoid Liposarcoma 3
  • Amyotrophic Lateral Sclerosis 6 2
  • Translocated In Liposarcoma 2
  • RNA-Binding Protein FUS 3
  • FUS/ERG Fusion Protein 3
  • Fus-Like Protein 3
  • HNRNPP2 3
  • POMP75 3
  • POMp75 4
  • ETM4 3
  • FUS1 3
  • ALS6 3

External Ids for FUS Gene

Previous HGNC Symbols for FUS Gene

  • ALS6

Previous GeneCards Identifiers for FUS Gene

  • GC16P030273
  • GC16P031688
  • GC16P031188
  • GC16P031227
  • GC16P031098
  • GC16P031191
  • GC16P028753
  • GC16P031180
  • GC16P031181
  • GC16P031184
  • GC16P031229
  • GC16P031234

Summaries for FUS Gene

Entrez Gene Summary for FUS Gene

  • This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

GeneCards Summary for FUS Gene

FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include Tremor, Hereditary Essential, 4 and Amyotrophic Lateral Sclerosis 6 With Or Without Frontotemporal Dementia. Among its related pathways are Translational Control and mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is EWSR1.

UniProtKB/Swiss-Prot for FUS Gene

  • Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.

Gene Wiki entry for FUS Gene

Additional gene information for FUS Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUS Gene

Genomics for FUS Gene

GeneHancer (GH) Regulatory Elements for FUS Gene

Promoters and enhancers for FUS Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J031178 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +1.1 1130 4.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 FUS SETD1A SRCAP ZNF764 RNF40 ENSG00000260267 FBRS SMG1P5 ENSG00000260304 PRR14
GH16J031092 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 56.8 -85.1 -85113 4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC VKORC1 ENSG00000280160 ENSG00000255439 SETD1A ZNF785 ZNF720 FUS ZNF689 SRCAP ZNF747
GH16J030393 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 49.3 -784.6 -784578 2.9 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SEPT1 ZNF48 SETD1A FUS INO80E SRCAP ZNF764 ZNF689 NPIPB12 RNF40
GH16J030367 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 37.2 -803.7 -803672 17 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 MYLPF TBC1D10B SRCAP SETD1A INO80E SMG1P5 SMG1P2 NPIPB12 ENSG00000260304 ZNF764
GH16J030353 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 47.2 -824.2 -824225 4.7 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 LOC101928707 PIR45213 CD2BP2 SETD1A NPIPB12 SRCAP FUS NPIPB13 INO80E ZNF747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FUS on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUS gene promoter:
  • STAT5A
  • NRSF form 2
  • NRSF form 1
  • FOXO1
  • FOXO1a

Genomic Locations for FUS Gene

Genomic Locations for FUS Gene
15,168 bases
Plus strand
14,762 bases
Plus strand

Genomic View for FUS Gene

Genes around FUS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUS Gene

Proteins for FUS Gene

  • Protein details for FUS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RNA-binding protein FUS
    Protein Accession:
    Secondary Accessions:
    • Q9H4A8

    Protein attributes for FUS Gene

    526 amino acids
    Molecular mass:
    53426 Da
    Quaternary structure:
    • Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.Interacts with LRSAM1 (PubMed:27615052).

    Three dimensional structures from OCA and Proteopedia for FUS Gene

    Alternative splice isoforms for FUS Gene


neXtProt entry for FUS Gene

Post-translational modifications for FUS Gene

  • Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine.
  • Ubiquitination at Lys365 and Lys316
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FUS Gene

Domains & Families for FUS Gene

Gene Families for FUS Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RRM TET family.
  • Belongs to the RRM TET family.
genes like me logo Genes that share domains with FUS: view

Function for FUS Gene

Molecular function for FUS Gene

UniProtKB/Swiss-Prot Function:
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
GENATLAS Biochemistry:
RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated leukemogenesis,rearranged in myxoid liposarcoma with translocation t(12;16) and in myeloid leukemia with translocation t(16;21)(q13;p11)

Phenotypes From GWAS Catalog for FUS Gene

Gene Ontology (GO) - Molecular Function for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003712 transcription coregulator activity IBA --
GO:0003713 transcription coactivator activity IDA 21909421
GO:0003723 RNA binding IBA,IEA --
genes like me logo Genes that share ontologies with FUS: view
genes like me logo Genes that share phenotypes with FUS: view

Human Phenotype Ontology for FUS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for FUS Gene

miRTarBase miRNAs that target FUS

Clone Products

  • Addgene plasmids for FUS

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FUS Gene

Localization for FUS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUS Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUS gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16365397
GO:0005654 nucleoplasm TAS,IDA --
GO:0005737 cytoplasm IEA --
GO:0005844 polysome IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with FUS: view

Pathways & Interactions for FUS Gene

genes like me logo Genes that share pathways with FUS: view

Pathways by source for FUS Gene

1 KEGG pathway for FUS Gene
2 Cell Signaling Technology pathways for FUS Gene

SIGNOR curated interactions for FUS Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0071277 cellular response to calcium ion IEA --
genes like me logo Genes that share ontologies with FUS: view

Drugs & Compounds for FUS Gene

(2) Drugs for FUS Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FUS: view

Transcripts for FUS Gene

Unigene Clusters for FUS Gene

Fused in sarcoma:
Representative Sequences:

Clone Products

  • Addgene plasmids for FUS

Alternative Splicing Database (ASD) splice patterns (SP) for FUS Gene

No ASD Table

Relevant External Links for FUS Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUS Gene

Protein differential expression in normal tissues from HIPED for FUS Gene

This gene is overexpressed in Lymph node (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUS Gene

Protein tissue co-expression partners for FUS Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUS Gene:


SOURCE GeneReport for Unigene cluster for FUS Gene:


mRNA Expression by UniProt/SwissProt for FUS Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FUS Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.7)
  • Intestine(3.9)
  • Kidney(3.8)
  • Skin(3.7)
  • Muscle(3.6)
  • Bone marrow(3.4)
  • Eye(3.4)
  • Heart(3.4)
  • Lymph node(3.3)
  • Adrenal gland(3.1)
  • Gall bladder(3.1)
  • Spleen(3.1)
  • Stomach(3.1)
  • Thyroid gland(3.1)
  • Blood(3)
  • Pancreas(2.7)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FUS Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • salivary gland
  • skull
  • tongue
  • vocal cord
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
  • biliary tract
  • liver
  • stomach
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with FUS: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FUS Gene

Orthologs for FUS Gene

This gene was present in the common ancestor of animals.

Orthologs for FUS Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUS 34
  • 99 (a)
(Mus musculus)
Mammalia Fus 34
  • 97 (a)
(Canis familiaris)
Mammalia FUS 34
  • 96 (a)
(Bos Taurus)
Mammalia FUS 34
  • 96 (a)
(Monodelphis domestica)
Mammalia FUS 34
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia FUS 34
  • 91 (a)
(Anolis carolinensis)
Reptilia FUS 34
  • 84 (a)
African clawed frog
(Xenopus laevis)
Amphibia fus-prov 33
(Danio rerio)
Actinopterygii fus 34
  • 65 (a)
zgc56390 33
fruit fly
(Drosophila melanogaster)
Insecta caz 34
  • 42 (a)
CG14718 34
  • 25 (a)
Species where no ortholog for FUS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUS Gene

Gene Tree for FUS (if available)
Gene Tree for FUS (if available)
Evolutionary constrained regions (ECRs) for FUS: view image

Paralogs for FUS Gene

Paralogs for FUS Gene

(3) SIMAP similar genes for FUS Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FUS: view

Variants for FUS Gene

Sequence variations from dbSNP and Humsavar for FUS Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1032691728 uncertain-significance, Amyotrophic Lateral Sclerosis, Dominant 31,190,287(+) G/A/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1052352 benign, not specified, Amyotrophic Lateral Sclerosis, Dominant, Amyotrophic lateral sclerosis type 6 31,183,958(+) C/T 5_prime_UTR_variant, coding_sequence_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, synonymous_variant, upstream_transcript_variant
rs1057518893 uncertain-significance, Dystonia, Myoclonus 31,180,237(+) GGCG/G genic_upstream_transcript_variant, intron_variant
rs114772555 likely-benign, Amyotrophic Lateral Sclerosis, Dominant 31,192,427(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs115626460 likely-benign, Amyotrophic Lateral Sclerosis, Dominant 31,192,064(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FUS Gene

Variant ID Type Subtype PubMed ID
nsv457483 CNV loss 19166990
nsv571820 CNV loss 21841781

Variation tolerance for FUS Gene

Residual Variation Intolerance Score: 13.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.88; 35.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUS Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUS Gene

Disorders for FUS Gene

MalaCards: The human disease database

(52) MalaCards diseases for FUS Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FUS in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3. {ECO:0000269 PubMed:7503811}.
  • Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG. {ECO:0000269 PubMed:8187069}.
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. {ECO:0000269 PubMed:11063792}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein. {ECO:0000269 PubMed:11063792}.
  • Amyotrophic lateral sclerosis 6, with or without frontotemporal dementia (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:19251627, ECO:0000269 PubMed:19251628, ECO:0000269 PubMed:19861302, ECO:0000269 PubMed:20124201, ECO:0000269 PubMed:27604643}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:22863194}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FUS Gene

myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation

Additional Disease Information for FUS

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FUS: view

Publications for FUS Gene

  1. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PMID: 7503811) Rabbitts TH … Nathan P (Nature genetics 1993) 2 3 4 22 58
  2. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PMID: 19251627) Kwiatkowski TJ … Brown RH (Science (New York, N.Y.) 2009) 2 3 4 58
  3. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PMID: 19251628) Vance C … Shaw CE (Science (New York, N.Y.) 2009) 2 3 4 58
  4. Human POMp75 is identified as the pro-oncoprotein TLS/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation. (PMID: 10442642) Bertrand P … Lopez BS (Oncogene 1999) 3 4 22 58
  5. Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China. (PMID: 27604643) Hou L … Shen L (Scientific reports 2016) 3 4 58

Products for FUS Gene